MyBioSource.com's Anti-PER2 Antibody is a Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Anti-PER2 Antibody was generated using PER2 as the antigen and it reacts with Human.
Description
Description: Rabbit IgG polyclonal antibody for Period circadian protein homolog 2(PER2) detection. Tested with WB in Human.
Background: The PER2 gene encodes the period circadian protein homolog 2 protein in humans. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER2 is mapped to 2q37.3. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. PER2 is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. What's more, the PER2 gene also functions in tumor suppression by regulating DNA damage-responsive pathways